TY - JOUR AU - Emil Mois AU - Florin Graur AU - Roxana Sechel AU - Nadim Al-Hajjar PY - 2016/04/21 Y2 - 2024/03/29 TI - Mckittrick-Wheelock syndrome: A rare case report of acute renal failure JF - Medicine and Pharmacy Reports JA - Medicine and Pharmacy Reports VL - 89 IS - 2 SE - Case Report DO - 10.15386/cjmed-536 UR - https://medpharmareports.com/index.php/mpr/article/view/536 AB - Giant tubular-villous adenoma of the rectum can determine secretory diarrhea, associated with a depleting syndrome of prerenal acute renal failure, hyponatremia, hypokalemia and hypoproteinemia. These symptoms are known as the McKittrick-Wheelock syndrome, and there are about 50 cases reported in literature. We present the case of a 59-year-old woman presented to our emergency department with abdominal pain, prerenal azotemia, and electrolyte disturbances with a background of chronic diarrhea, caused by a giant rectal tumor. Conservative therapy initially improved and normalized renal function, and made surgical resection of the tumor possible. ER -