Genetic Polymorphism of VKORK1 and KLOTHO Genes Associated With Atherosclerosis
Abstract
Atherosclerosis Is A Complex Multifocal Arterial Disease Involving Interactions Of Multiple Genetic And Environmental Factors. Advances In Techniques Of Molecular Genetics Have Revealed That Genetic Polymorphisms Significantly Influence Susceptibility To Atherosclerotic Vascular Diseases. A Large Number Of Candidate Genes, Genetic Polymorphisms And Susceptibility Loci Associated With Atherosclerotic Diseases Have Been Identified In Recent Years And Their Number Is Rapidly Increasing [1]. Genetic Studies Have Suggested That Klotho Gene Polymorphism And Vitamin K-epoxide Reductase Complex Subunit 1 Gene, Vkorc 1 Might Be Associated With Vascular Atherosclerosis And Calcification. In This Review We Focus On Klotho And Vkorc 1 Gene Polymorphisms And Their Potential Role In The Physiopathology Of Atherosclerosis.