Genetic Polymorphism of VKORK1 and KLOTHO Genes Associated With Atherosclerosis

Abstract

Atherosclerosis Is A Complex Multifocal Arterial Disease Involving Interactions  Of Multiple Genetic And Environmental Factors. Advances In Techniques Of Molecular  Genetics Have Revealed That Genetic Polymorphisms Significantly Influence Susceptibility  To Atherosclerotic Vascular Diseases. A Large Number Of Candidate Genes, Genetic  Polymorphisms And Susceptibility Loci Associated With Atherosclerotic Diseases Have  Been Identified In Recent Years And Their Number Is Rapidly Increasing [1].  Genetic Studies Have Suggested That Klotho Gene Polymorphism And Vitamin  K-epoxide Reductase Complex Subunit 1 Gene, Vkorc 1 Might Be Associated With  Vascular Atherosclerosis And Calcification. In This Review We Focus On Klotho And  Vkorc 1 Gene Polymorphisms And Their Potential Role In The Physiopathology Of  Atherosclerosis.