Botulinum Toxin in the Treatment of Cystitis

Abstract

Objective. This study will follow the effectiveness of treatment of chronic cystitis in menopausal women, associated with overactive bladder syndrome, performed by endoscopic injection of botulinum toxin type A to patients who previously attended drug treatment and bladder instilational treatment but with persistence of clinical manifestations.

Materials and methods. We studied 43 patients, in menopause with chronic recurrent cystitis and overactive bladder. The data were statistically analyzed by descriptive analysis and linear regression. We used Chi-square, T-Student test. Treatment was performed by injecting botulinum toxin solution.

Results. The patients were divided in 2 groups. Group A, 22 patients underwent instillational treatment. Group B, 21 patients, underwent endovezical injection of botulinum toxin type A. 18 patients in group A after treatment showed an initial improvement of symptoms; after 3 months evaluation the improvement was in 63.63 % and after 6 months only 54.54%. The B group after 2 weeks of treatment 85.71% had remission of symptoms.

Conclusions. Endoscopic treatment by injection of type A botulinum toxin in bladder mucosa represents a feasible therapeutic approach.