A review on the importance of genotyping and phenotyping in fluoropyrimidine treatment

Authors

  • Andrada-Larisa Deac
  • Claudia Cristina Burz
  • Horea Florin Bocșe
  • Ioana Corina Bocșan
  • Anca-Dana Buzoianu

DOI:

https://doi.org/10.15386/mpr-1564

Keywords:

chemotherapy, fluoropyrimidine treatment, toxicity

Abstract

Fluoropyrimidines, after more than 50 years from their discovery, are still the treatment of many types of cancer, and it is estimated that two million patients receive fluoropyrimidine therapy annually. The toxicity associated with fluoropyrimidines affects 30-40% of patients and some adverse effects can be lethal.

Dihydroypyrimidine dehydrogenase is the main enzyme in the catabolism of 5-FU and DPD activity deficiency can cause important toxicity. This is an important reason to determine DPD activity in order to improve patient safety and to limit potential life-threating toxicity.

At presentmultiple phenotypic and genotypic methods are available for the determination of DPD activity, some of these methods have proven their usefulness in practice, and yet they are not routinely recommended in clinical practice.

This review is another statement of the importance of the determination of DPD status, the phenotypic and genotypic methods that are available and can be used.

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Published

2020-03-25

How to Cite

1.
Deac A-L, Burz CC, Bocșe HF, Bocșan IC, Buzoianu A-D. A review on the importance of genotyping and phenotyping in fluoropyrimidine treatment. Med Pharm Rep [Internet]. 2020 Mar. 25 [cited 2025 Oct. 6];93(3):223-30. Available from: https://medpharmareports.com/index.php/mpr/article/view/1564

Issue

Section

Reviews