Isoprostanes - the Gold Standard of the Oxidative Stress Assessment in Vivo

Abstract

Oxidative stress seems to be involved in the generation and maintenance of several clinical entities. Several in vitro markers of oxidative stress are available, but most are of limited value in vivo because of low sensitivity and/or specificity. Isoprostanes, prostaglandin’s isomers, are a fundamental class of products generated by the oxidative stress reactions. F 2 Isoprostanes are a group of 64 isomeric compounds of prostaglandin F 2α . Determination of F 2 Isoprostanes seems to be the most efficient method to quantify oxidative stress in vivo and has become the gold standard of the assessment of oxidative reactions.