Updates on the 2016 World Health Organization Classification of Pediatric Tumors of the Central Nervous System - a systematic review

Authors

  • Maria Margareta Cosnarovici
  • Rodica Voichița Cosnarovici
  • Doina Piciu

DOI:

https://doi.org/10.15386/mpr-1811

Keywords:

brain tumors, children, molecular diagnosis, prognosis, treatment

Abstract

Tumors of the central nervous system (CNS) represent the main cause of death through solid tumors in children and the second most frequent neoplasm in this patient group. The poor survival rate is due to many factors, such as the large diversity of morphological features, the particular micro-environmental characteristics of the nervous tissue, the relative rareness in relation to other childhood diseases, which leads to late diagnosis and the limited effectiveness of the available treatment options. Up until 2016, brain tumors were classified according to their histologic features. The new 2016 World Health Organization (WHO) Classification of CNS tumors incorporates molecular features, alongside the immunohistology, in order to provide a more accurate understanding of the disease. The treatment consists of surgery, radiation therapy and chemotherapy. We decided to review the literature on this pathology, in order to show the importance of the recent discoveries in this field.

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Published

2021-07-20

How to Cite

1.
Cosnarovici MM, Cosnarovici RV, Piciu D. Updates on the 2016 World Health Organization Classification of Pediatric Tumors of the Central Nervous System - a systematic review. Med Pharm Rep [Internet]. 2021 Jul. 20 [cited 2025 Oct. 3];94(3):282-8. Available from: https://medpharmareports.com/index.php/mpr/article/view/1811

Issue

Section

Reviews