Progressive disseminated histoplasmosis in idiopathic CD4 lymphocytopenia an underdiagnosed combination - a case report

Authors

  • Prakrati Yadav
  • Deepak Kumar
  • Gopal Krishana Bohra
  • Mahendra Kumar Garg
  • Jyotsna N Bharti
  • Abhishek HL Purohit
  • Durga Shankar Meena

DOI:

https://doi.org/10.15386/mpr-1908

Keywords:

Progressive Disseminated Histoplasmosis, Idiopathic CD4 Lymphocytopenia, immunocompromised individuals, HIV negative individuals.

Abstract

Progressive disseminated histoplasmosis (PDH) usually presents as fever, anemia, leukopenia, hepatosplenomegaly, lymphadenopathy and pulmonary symptoms. There are few reports showed the association of Idiopathic CD4 lymphocytopenia (ICL) with histoplasmosis. We describe a 65-year-old female presented with history of fever, papulo-nodular rash and significant weight loss and diagnosed as progressive disseminated histoplasmosis. All immunocompromised conditions were ruled out.  In addition, her 2 consecutive CD4 counts were below 300. The patient was diagnosed with PDH associated with ICL. Patient showed significant improvement with liposomal amphotericin B and itraconazole. Absolute CD4 counts should be done in all cases of progressive disseminated histoplasmosis even in HIV negative individuals to rule out associated ICL.

Downloads

Published

2021-09-24

How to Cite

1.
Yadav P, Kumar D, Bohra GK, Garg MK, Bharti JN, Purohit AH, Meena DS. Progressive disseminated histoplasmosis in idiopathic CD4 lymphocytopenia an underdiagnosed combination - a case report. Med Pharm Rep [Internet]. 2021 Sep. 24 [cited 2025 Oct. 5];95(2):209-13. Available from: https://medpharmareports.com/index.php/mpr/article/view/1908

Issue

Section

Case Report