Association of Alzheimer’s disease and periodontitis - a systematic review and meta-analysis of evidence from observational studies

Authors

  • Sriram Kaliamoorthy Associate professor, Department of dentistry,Vinaka mission's Medical College and Hospital,Karaikal, Puducherry, India
  • Mahendirakumar Nagarajan Associate Professor, Department of Prosthodontics, and Crown & Bridge, Raja Muthiah Dental College and Hospital , Annamalai University, Chidambaram, Tamilnadu , India
  • Vijayparthiban Sethuraman Assistant Professor, Department of Dental Surgery, Thanjavur Medical College, The Tamilnadu Dr.M.G.R Medical University, Tamilnadu , India
  • Kavitha Jayavel Associate Professor, Department of Periodontics and Implantology, Raja Muthiah Dental College and Hospital , Annamalai University, Chidambaram, Tamilnadu , India
  • Vijayalakshmi Lakshmanan Associate Professor, Department of Oral Medicine and Radiology, Raja Muthiah Dental College and Hospital , Annamalai University, Chidambaram, Tamilnadu , India
  • Santosh Palla Consultant, Oral Medicine and Radiology, Sun Dental Care,660/4, Thiruvottiyur High Road, Tondiarpet, Chennai, Tamil Nadu- 600081, India

DOI:

https://doi.org/10.15386/mpr-2278

Keywords:

Alzheimer’s disease, meta-analysis, neurology, periodontitis, psychiatry

Abstract

The relationship between periodontitis (or periodontal disease) with Alzheimer’s disease has been reported by various primary sources in the past decade, but not with a solid secondary research statement. A systematic review and meta-analysis was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered (Reference number: CRD42020185264) with PROSPERO (International prospective register for systematic reviews). A literature search was conducted on specific databases for suitable articles in English language. Out of 612 studies selected, 41 underwent full-text analysis; five studies were eligible for systematic review, and 3 for meta-analysis. Meta-analysis was performed with tests for sensitivity and statistical heterogeneity followed by calculation of summary effect measures in terms of odds ratio (OR) and 95% confidence interval (CI). The results of this review showed a significant association between periodontitis and Alzheimer’s disease in the meta-analysis [OR 1.67 (1.21–2.32)].

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Published

2022-02-11

How to Cite

1.
Kaliamoorthy S, Nagarajan M, Sethuraman V, Jayavel K, Lakshmanan V, Palla S. Association of Alzheimer’s disease and periodontitis - a systematic review and meta-analysis of evidence from observational studies. Medicine and Pharmacy Reports [Internet]. 2022 Feb. 11 [cited 2025 May 22];95(2):144-51. Available from: https://medpharmareports.com/index.php/mpr/article/view/2278

Issue

Vol. 95 No. 2 (2022)

Section

Reviews

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