Sarcopenia assessed by total psoas index – is it correlated with post-operative complications in all digestive cancers?

Authors

  • Carmen Haiducu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  • Catalin Adrian Buzea 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2Cardiology Department, Colentina Clinical Hospital, Bucharest, Romania
  • Caterina Delcea 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2Cardiology Department, Colentina Clinical Hospital, Bucharest, Romania
  • Vladislav Brasoveanu 3Dan Setlacec General Surgery and Hepatic Transplant Department, Fundeni Clinical Institute, Bucharest, Romania 4Titu Maiorescu University, Bucharest, Romania
  • Cristian Mugur Grasu 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 5Radiology Department, Fundeni Clinical Institute, Bucharest, Romania
  • Gheorghe-Andrei Dan 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2Cardiology Department, Colentina Clinical Hospital, Bucharest, Romania

DOI:

https://doi.org/10.15386/mpr-2539

Keywords:

sarcopenia, total psoas index, digestive cancer, post-operative complications

Abstract

Background and aims. In cancer patients sarcopenia may be a predictor for postoperative complications of curative or palliative surgery. Several indices including the total psoas area index (TPAI) are proposed for the diagnosis of this condition, but there is no validated cut-off point.

Our study aimed to assess the role of TPAI as a marker for sarcopenia and to compare the utility of previously proposed cut-off values for predicting post-operative complications in patients with digestive cancers undergoing surgery.

Methods. We retrospectively included all adult patients with digestive cancers admitted to a tertiary center for elective surgery between January and December 2019. Sarcopenia was considered based on TPAI evaluated on abdominal computed tomography (CT) and for analysis we used different cut-off points published by various authors. The primary endpoint was the occurrence of any complications as defined by the Clavien-Dindo classification. The secondary endpoints were fistula development, low– versus high-grade Clavien-Dindo post-operative complications, moderate or severe anemia at discharge, major bleeding, hypoalbuminemia at discharge, and decrease in albumin levels by at least 1g/dL.

Results. We included 155 patients with a mean age of 64.78 ± 11.40 years, of which 59.35% were males; 58.06% developed postoperative complications. TPAI evaluated as a continuous variable was not a predictor for the development of post-operative complications neither in the general study sample, nor in the gender subgroups of patients. Sarcopenia defined by previously proposed cut-off values was not a predictor of the secondary end-points either.

Conclusion. TPAI as a sole parameter for defining sarcopenia was not a predictor for postoperative complications in patients undergoing surgery for digestive neoplasia.

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Published

2022-06-09

How to Cite

1.
Haiducu C, Buzea CA, Delcea C, Brasoveanu V, Grasu CM, Dan G-A. Sarcopenia assessed by total psoas index – is it correlated with post-operative complications in all digestive cancers?. Med Pharm Rep [Internet]. 2022 Jun. 9 [cited 2025 Jul. 14];96(3):274-82. Available from: https://medpharmareports.com/index.php/mpr/article/view/2539

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Section

Original Research