TP53 gene implications in prostate cancer evolution: potential role in tumor classification

Authors

  • Vlad Horia Schitcu
  • Lajos Raduly
  • Oana Zanoaga
  • Ancuta Jurj
  • Vlad Cristian Munteanu
  • Liviuta Budisan
  • Bogdan Petrut
  • Cornelia Braicu
  • Ioan Coman
  • Ioana Berindan-Neagoe

DOI:

https://doi.org/10.15386/mpr-2639

Keywords:

prostatic neoplasms, adenocarcinoma, microRNAs, biomarkers

Abstract

Background and aims. Prostate adenocarcinoma (PRAD) is a complex disease that can be driven by alterations in both coding and noncoding genes. Recent research has identified coding and non-coding genes that are considered to play important roles in prostate cancer evolution and which may be used as biomarkers for disease diagnosis, prognosis, and treatment. TP53 is a critical hub gene in prostate cancer. Advanced studies have demonstrated the crosstalk between coding and non-coding RNAs, particularly microRNAs (miRNAs).

Methods. In this study, we investigated the roundabout of TP53 and their regulatory miRNAs (miR-15a-5p, miR-34a-5p, and miR-141-3p) based on the TCGA data set. We validated an additional patient cohort of 28 matched samples of patients with PRAD at tissue and plasma level.

Results. Therefore, using the UALCAN online database, we evaluated the expression level in PRAD of these genes revealing overexpression of TP53. qRT-PCR validation step endorsed the expression level for these genes. Additionally, we evaluated the expression level of the four key miRNAs (miR-15a-5p, miR-34a-5p, and miR-141-3p) interconnected as a network at tissue and plasma levels.

Conclusions. Through these results, we demonstrated the essential function of TP53 and its associated miRNAs that play a significant role in tumor control, highlighting miRNAs’ potential as future therapeutic targets and biomarkers with important implications in managing prostate cancer.

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Published

2023-07-14

How to Cite

1.
Schitcu VH, Raduly L, Zanoaga O, Jurj A, Munteanu VC, Budisan L, Petrut B, Braicu C, Coman I, Berindan-Neagoe I. TP53 gene implications in prostate cancer evolution: potential role in tumor classification. Med Pharm Rep [Internet]. 2023 Jul. 14 [cited 2025 Oct. 6];96(4):384-91. Available from: https://medpharmareports.com/index.php/mpr/article/view/2639

Issue

Vol. 96 No. 4 (2023)

Section

Original Research

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