Clinical aspects encountered in patients with portopulmonary hypertension

Authors

  • Patricia Bulacu-Durand
  • Viorel Biciusca
  • Sergiu-Marian Cazacu
  • Sorina Ionelia Stan
  • Petre Ciobanu
  • Mihail-Virgil Boldeanu
  • Maria Cristina Bezna
  • Octavian Istratoaie

DOI:

https://doi.org/10.15386/mpr-2851

Keywords:

portopulmonary hypertension (PoPH), liver cirrhosis, portal hypertension, right heart failure

Abstract

Portopulmonary hypertension (PoPH) is a condition characterized by the elevation of the arterial pulmonary pressure because of portal hypertension which leads to right heart failure and finally death. The most common cause of PoPH is hepatic cirrhosis, but patients with non-cirrhotic portal hypertension can also develop this complication. It is considered that between 2% and 10% of patients with portal hypertension can develop PoPH, and it is a major determinant factor of prognosis, especially in the context of liver transplantation. Clinically, the symptoms are nonspecific and are usually due to worsening right ventricular dysfunction. The treatment of PoPH consists of vasomodulating therapy, but several future challenges remain in the treatment of PoPH patients. In the absence of medical treatment or liver transplantation, the 1-year survival rate is 35%-46% and 5-year survival rate is 4-14%. Despite advances in understanding this disease, several unresolved questions remain regarding screening, diagnosis, treatment, and liver transplantation.

 

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Published

2025-09-12

How to Cite

1.
Bulacu-Durand P, Biciusca V, Cazacu S-M, Stan SI, Ciobanu P, Boldeanu M-V, Bezna MC, Istratoaie O. Clinical aspects encountered in patients with portopulmonary hypertension. Med Pharm Rep [Internet]. 2025 Sep. 12 [cited 2025 Oct. 5];. Available from: https://medpharmareports.com/index.php/mpr/article/view/2851

Issue

Section

Reviews