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Copyright
© Clujul Medical, 2019
Affiliations
Anda Maria Ster
Universitatea de Medicina si Farmacie Iuliu Hatieganu
Radu Anghel Popp
Universitatea de Medicina si Farmacie Iuliu Hatieganu Cluj
Felicia Maria Petrisor
Universitatea de Medicina si Farmacie Iuliu Hatieganu Cluj
Cristina Stan
Universitatea de Medicina si Farmacie Iuliu Hatieganu Cluj
Spitalul Clinic Judetean de Urgenta Cluj
Victor Ioan Pop
Universitatea de Medicina si Farmacie Iuliu Hatieganu Cluj
How to Cite
Glaucoma Pathophysyology and Therapeutic Implication
Abstract
Primary Open Angle Glaucoma(POAG) is a chronic, irreversible optic neuropathy leading to the progressive death of retinal ganglion cells, clinically observed as silent visual field loss along with a decrease in colour and contrast sensitivity. Multiple pathogenic theories have been issued and some of them have proven their involvement in disease development: mechanical damage due to increased intraocular pressure, variable susceptibility of the optic nerve, mutation in specific nuclear genes, increased glutamate levels, alteration in nitric oxide (NO) metabolism, changes in the mitochondrial genome, vascular dysregulation, and toxic effects and oxidative damage cause by reactive oxygen species1.
The aim of this article is to highlight the pathogenic role of vascular dysregulation and reactive oxygen species in POAG with the further possibilities for prevention and gene therapy.