THE RELATIONSHIP BETWEEN SERUM LIPID FRACTIONS AND HEART RATE VARIABILITY IN DIABETIC PATIENTS WITH STATIN THERAPY

Authors

  • Anamaria Raluca Badea
  • Laurentiu Nedelcu
  • Madalina Valeanu
  • Dumitru Zdrenghea

DOI:

https://doi.org/10.15386/cjmed-313

Keywords:

type 2 diabetes, statin therapy, heart rate variability, lipid fractions

Abstract

Background and aims. The aim of this study is to identify and highlight the relationship between serum lipid fractions and heart rate variability in diabetic patients receiving statin therapy.

Patients and methods. The study was performed in a group of 87 type 2 diabetic patients on statin associated therapy. All patients were on Holter ECG 24 hours monitored with three channel monitor (Labtech ECG Holter monitor), and data were analyzed on a commercially available software (Cardiospy PC SW/EV 5.02.06.02). Concentrations of biochemical parameters were determined using specific enzymatic assays on an autoanalyzer Olympus AU 680. In the studied patients, we analyzed Holter/24 hours monitoring reports with respect to heart rate variability indexes, arrhythmic events and myocardial ischemia.

Results. It was noticed that the mean values of serum TG were slightly elevated, TC levels were close to the limits specified by the guidelines for diabetic patients and for patients with cardiovascular diseases, with no significant differences between males and females. After analyzing the HRV in both time and frequency domains, we found no strong correlations between any of the HRV indexes and any of the lipid fractions.

Conclusions. The results suggest that statin therapy may reduce the autonomic impairment secondary to dyslipidemia.

Author Biographies

Anamaria Raluca Badea, Transilvania University Brasov

Internal Medicine

Laurentiu Nedelcu, Transilvania University of Brasov, Faculty of Medicine

Internal Medicine

Madalina Valeanu, Iuliu Hatieganu University of Medicine and Pharmacy CLuj-Napoca

Medical Informatics and Biostatistics

Dumitru Zdrenghea, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

Cardilogy - Recovery

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Published

2014-09-19

How to Cite

1.
Badea AR, Nedelcu L, Valeanu M, Zdrenghea D. THE RELATIONSHIP BETWEEN SERUM LIPID FRACTIONS AND HEART RATE VARIABILITY IN DIABETIC PATIENTS WITH STATIN THERAPY. Med Pharm Rep [Internet]. 2014 Sep. 19 [cited 2025 Oct. 6];87(3):152-8. Available from: https://medpharmareports.com/index.php/mpr/article/view/313

Issue

Vol. 87 No. 3 (2014)

Section

Original Research

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