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© Clujul Medical, 2019
Affiliations
Cristina Ioana Stoica
Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.
Ioana Ionuț
Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.
Adrian Pîrnău
National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Street, 400293, Cluj-Napoca, Romania.
Carmen Pop
University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, 400370, Cluj-Napoca, Romania.
Ancuța Rotar
University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, 400370, Cluj-Napoca, Romania.
Laurian Vlase
Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.
Smaranda Oniga
Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.
Ovidiu Oniga
Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.
How to Cite
Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines
Abstract
Background and aims. Synthesis of new potential antimicrobial agents and evaluation of their lipophilicity.
Methods. Ten new thiazolyl-oxadiazoline derivatives were synthesized and their structures were validated by 1H-NMR and mass spectrometry. The lipophilicity of the compounds was evaluated using the principal component analysis (PCA) method. The necessary data for applying this method were obtained by reverse-phase thin-layer chromatography (RP-TLC). The antimicrobial activities were tested in vitro against four bacterial strains and one fungal strain.
Results. The lipophilicity varied with the structure but could not be correlated with the antimicrobial activity, since this was modest.
Conclusions. We have synthesized ten new heterocyclic compounds. After their physical and chemical characterization, we determined their lipophilicity and screened their antimicrobial activity.