Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines

Authors

  • Cristina Ioana Stoica
  • Ioana Ionuț
  • Adrian Pîrnău
  • Carmen Pop
  • Ancuța Rotar
  • Laurian Vlase
  • Smaranda Oniga
  • Ovidiu Oniga

DOI:

https://doi.org/10.15386/cjmed-473

Keywords:

thiazolyl-oxadiazoline, lipophilicity, antibacterial, Candida albicans

Abstract

Background and aims. Synthesis of new potential antimicrobial agents and evaluation of their lipophilicity.

Methods. Ten new thiazolyl-oxadiazoline derivatives were synthesized and their structures were validated by 1H-NMR and mass spectrometry. The lipophilicity of the compounds was evaluated using the principal component analysis (PCA) method. The necessary data for applying this method were obtained by reverse-phase thin-layer chromatography (RP-TLC). The antimicrobial activities were tested in vitro against four bacterial strains and one fungal strain.

Results. The lipophilicity varied with the structure but could not be correlated with the antimicrobial activity, since this was modest.

Conclusions. We have synthesized ten new heterocyclic compounds. After their physical and chemical characterization, we determined their lipophilicity and screened their antimicrobial activity.

Author Biographies

Cristina Ioana Stoica, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.

Therapeutical Chemistry

Ioana Ionuț, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.

Pharmaceutical Chemistry

Adrian Pîrnău, National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Street, 400293, Cluj-Napoca, Romania.

Molecular and Biomolecular Physics

Carmen Pop, University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, 400370, Cluj-Napoca, Romania.

Food Science and Technology

Ancuța Rotar, University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, 400370, Cluj-Napoca, Romania.

Food Science and Technology

Laurian Vlase, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.

Pharmaceutical Technology and Biopharmaceutics

Smaranda Oniga, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.

Therapeutical Chemistry

Ovidiu Oniga, Iuliu Haţieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania.

Pharmaceutical Chemistry

Downloads

Additional Files

Published

2015-09-21

How to Cite

1.
Stoica CI, Ionuț I, Pîrnău A, Pop C, Rotar A, Vlase L, Oniga S, Oniga O. Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines. Med Pharm Rep [Internet]. 2015 Sep. 21 [cited 2025 Oct. 3];88(4):521-9. Available from: https://medpharmareports.com/index.php/mpr/article/view/473

Issue

Vol. 88 No. 4 (2015)

Section

Original Research

License

The authors are required to transfer the copyright of the published paper to the journal. This is done by agreeing to sign the Copyright Assignment Form. Whenever the case, authors are also required to send permissions to reproduce material (such as illustrations) from the copyright holder.

 Creative Commons License
The papers published in the journal are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.