IRON, INFLAMMATION AND INVASION OF CANCER CELLS

Authors

  • Eva Fischer-Fodor
  • Natalia Miklasova
  • Ioana Berindan-Neagoe
  • Bhaskar Saha

DOI:

https://doi.org/10.15386/cjmed-492

Keywords:

iron metabolism, cancer, hepcidin, targeted therapy

Abstract

Chronic inflammation is associated with the metastasis of tumor cells evolving from a benign tumor to disseminating cancer.  Such a metastatic progression is fostered by the angiogenesis propelled by various mediators interacting at the site of tumor growth. Angiogenesis causes two major changes that are assisted by altered glycosylation and neo-antigen presentation by the cancer cells. The angiogenesis-promoted pathological changes include enhanced inflammation and degradation of tissue matrices releasing tumor cells from the site of its origin. The degraded tumor cells release the neo-antigens resulting from altered glycosylation. Presentation of neo-antigens to T cells escalates metastasis and inflammation. Inflammasome activation and inflammation in several infections are regulated by iron. Based on the discrete reports, we propose a link between iron, inflammation, angiogenesis and tumor growth. Knowing the link better may help us formulate a novel strategy for cancer immunotherapy.

Author Biographies

Eva Fischer-Fodor, Institute of Oncology "Prof.Dr.I.Chiricuta"

Research Department

Natalia Miklasova, Faculty of Pharmacy, Comenius University, 83232 Bratislava

Theory of Drugs

Ioana Berindan-Neagoe, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, 8, Babes str, RO-400012, Cluj Napoca

Research Center of Functional Genomics, Biomedicine and Translational Medicine

Bhaskar Saha, National Centre for Cell Science, Ganeshkhind, Pune 411007

Pathogenesis and Cellular Response

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Published

2015-07-22

How to Cite

1.
Fischer-Fodor E, Miklasova N, Berindan-Neagoe I, Saha B. IRON, INFLAMMATION AND INVASION OF CANCER CELLS. Med Pharm Rep [Internet]. 2015 Jul. 22 [cited 2025 Sep. 20];88(3):272-7. Available from: https://medpharmareports.com/index.php/mpr/article/view/492

Issue

Vol. 88 No. 3 (2015)

Section

Reviews

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