VEGF involvement in psoriasis

Authors

  • Mihaela Elena Marina
  • Iulia Ioana Roman
  • Anne-Marie Constantin
  • Carmen Mihaela Mihu
  • Alexandru Dumitru Tătaru

DOI:

https://doi.org/10.15386/cjmed-494

Keywords:

VEGF, VEGFR, psoriasis

Abstract

Vascular endothelial growth factor (VEGF) is a key growth factor, regulating the neovascularization, during embryogenesis, skeletal growth, reproductive functions and pathological processes. The VEGF receptors (VEGFR) are present in endothelial cells and other cell types, such as vascular smooth muscle cells, hematopoietic stem cells, monocytes, neurons, macrophages, and platelets.

Angiogenesis is initiated by the activation of vascular endothelial cells through several factors. The excess dermal vascularity and VEGF production are markers of psoriasis.

The pathological role of VEGF/VEGFR signaling during the psoriasis onset and evolution makes it a promising target for the treatment of psoriasis. Antibodies and other types of molecules targeting the VEGF pathway are currently evaluated in arresting the evolution of psoriasis.

Author Biographies

Mihaela Elena Marina, Universitatea de Medicina si Farmacie ''Iuliu Hatieganu'' Cluj Napoca

Catedra Histologie UMF ''Iuliu Hatieganu'' Cluj Napoca

Iulia Ioana Roman, Physiology Discipline, University of Medicine and Pharmacy''Iuliu Hatieganu'' Cluj Napoca

Functional Sciences Department 2

Anne-Marie Constantin, Histology Discipline, University of Medicine and Pharmacy''Iuliu Hatieganu'' Cluj Napoca

Morphological Sciences Department 1, UMPh ''Iuliu Hatieganu'' Cluj Napoca

Carmen Mihaela Mihu, Histology Discipline, University of Medicine and Pharmacy''Iuliu Hatieganu'' Cluj Napoca

Morphological Sciences Department 1, UMPh ''Iuliu Hatieganu'' Cluj Napoca

Alexandru Dumitru Tătaru, Dermatology Discipline, University of Medicine and Pharmacy''Iuliu Hatieganu'' Cluj Napoca

Medical Specialities, Department 6, University of Medicine and Pharmacy''Iuliu Hatieganu'' Cluj Napoca

Downloads

Additional Files

Published

2015-07-22

How to Cite

1.
Marina ME, Roman II, Constantin A-M, Mihu CM, Tătaru AD. VEGF involvement in psoriasis. Med Pharm Rep [Internet]. 2015 Jul. 22 [cited 2025 Oct. 31];88(3):247-52. Available from: https://medpharmareports.com/index.php/mpr/article/view/494

Issue

Vol. 88 No. 3 (2015)

Section

Reviews

License

The authors are required to transfer the copyright of the published paper to the journal. This is done by agreeing to sign the Copyright Assignment Form. Whenever the case, authors are also required to send permissions to reproduce material (such as illustrations) from the copyright holder.

 Creative Commons License
The papers published in the journal are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.