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Copyright
© Clujul Medical, 2019
Affiliations
Valentina Pileczki
1. Faculty of Pharmacy, ”Iuliu Hatieganu” University of Medicine and Pharmacy
2. The Research Center for Functional Genomics, Biomedicine and Translational Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy
Roxana Cojocneanu-Petric
2. The Research Center for Functional Genomics, Biomedicine and Translational Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy
3. Faculty of Biology "Babes-Bolyai" University
Mahafarin Maralani
Molecular medicine department, Dokuz Eylul University, Izmir, Turkey
Ioana Berindan Neagoe
2.The Research Center for Functional Genomics, Biomedicine and Translational Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy
Robert Sandulescu
1. Faculty of Pharmacy, ”Iuliu Hatieganu” University of Medicine and Pharmacy
How to Cite
MicroRNAs as regulators of apoptosis mechanisms in cancer
Abstract
MicroRNAs or miRNAs are small non-coding RNAs that regulate gene expression. Their discovery has brought new knowledge in biological processes of cancer. Involvement of miRNAs in cancer development includes several major pathways from cell transformation to tumor cell development, metastasis and resistance to treatment. The first part of this review discusses miRNAs function in the intrinsic and extrinsic pathways of apoptosis. Due to the fact that many miRNAs that regulate apoptosis have been shown to play a major role in tumor cell resistance to treatment, in the second part of the review we aim at discussing miRNAs potential in becoming curative molecules.