MicroRNAs as regulators of apoptosis mechanisms in cancer

Authors

  • Valentina Pileczki
  • Roxana Cojocneanu-Petric
  • Mahafarin Maralani
  • Ioana Berindan Neagoe
  • Robert Sandulescu

DOI:

https://doi.org/10.15386/cjmed-512

Keywords:

microRNAs, cancer, apoptosis, cancer therapy

Abstract

MicroRNAs or miRNAs are small non-coding RNAs that regulate gene expression. Their discovery has brought new knowledge in biological processes of cancer. Involvement of miRNAs in cancer development includes several major pathways from cell transformation to tumor cell development, metastasis and resistance to treatment. The first part of this review discusses miRNAs function in the intrinsic and extrinsic pathways of apoptosis. Due to the fact that many miRNAs that regulate apoptosis have been shown to play a major role in tumor cell resistance to treatment, in the second part of the review we aim at discussing miRNAs potential in becoming curative molecules.    

   

Author Biographies

Valentina Pileczki, 1. Faculty of Pharmacy, ”Iuliu Hatieganu” University of Medicine and Pharmacy 2. The Research Center for Functional Genomics, Biomedicine and Translational Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy

Department of Analytical Chemistry and Research Center for Functional Genomics, Biomedicine and Translational Medicine

Roxana Cojocneanu-Petric, 2. The Research Center for Functional Genomics, Biomedicine and Translational Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy 3. Faculty of Biology "Babes-Bolyai" University

The Research Center for Functional Genomics, Biomedicine and Translational Medicine

Mahafarin Maralani, Molecular medicine department, Dokuz Eylul University, Izmir, Turkey

Molecular medicine department, Dokuz Eylul University, Izmir, Turkey

Ioana Berindan Neagoe, 2.The Research Center for Functional Genomics, Biomedicine and Translational Medicine, ”Iuliu Hatieganu” University of Medicine and Pharmacy

The Research Center for Functional Genomics, Biomedicine and Translational Medicine

Robert Sandulescu, 1. Faculty of Pharmacy, ”Iuliu Hatieganu” University of Medicine and Pharmacy

Department of Analytical Chemistry

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Published

2016-02-02

How to Cite

1.
Pileczki V, Cojocneanu-Petric R, Maralani M, Berindan Neagoe I, Sandulescu R. MicroRNAs as regulators of apoptosis mechanisms in cancer. Med Pharm Rep [Internet]. 2016 Feb. 2 [cited 2025 Oct. 5];89(1):50-5. Available from: https://medpharmareports.com/index.php/mpr/article/view/512

Issue

Vol. 89 No. 1 (2016)

Section

Reviews

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