In vitro comparative models for canine and human breast cancers

Authors

  • Simona Visan
  • Ovidiu Balacescu
  • Ioana Berindan-Neagoe
  • Cornel Catoi

DOI:

https://doi.org/10.15386/cjmed-519

Keywords:

canine mammary cancer, canine model, human breast cancer, cancer cell lines

Abstract

During the past four decades, an increased number of similarities between canine mammary tumors and human breast cancer have been reported: molecular, histological, morphological, clinical and epidemiological, which lead to comparative oncological studies. One of the most important goals in human and veterinary oncology is to discover potential molecular biomarkers that could detect breast cancer in an early stage and to develop new effective therapies. Recently, cancer cell lines have successfully been used as an in vitro model to study the biology of cancer, to investigate molecular pathways and to test the efficiency of anticancer drugs. Moreover, establishment of an experimental animal model for the study of human breast cancer will improve testing potential anti-cancer therapies and the discovery of effective therapeutic schemes suitable for human clinical trials.

In this review, we collected data from previous studies that strengthen the value of canine mammary cancer cell lines as an in vitro model for the study of human breast cancer.

Author Biographies

Simona Visan, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Cluj-Napoca, Romania The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania

Department of Pathologic Anatomy, Necropsy and Veterinary Forensic Medicine

Department of Functional Genomics, Proteomics and Experimental Pathology

Ovidiu Balacescu, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania

Department of Functional Genomics, Proteomics and Experimental Pathology

Ioana Berindan-Neagoe, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania MD Anderson Cancer Center, Houston, Texas , USA

Department of Functional Genomics, Proteomics and Experimental Pathology

Research Center for Functional Genomics, Biomedicine and Translational Medicine

Department of Immunology 

Department of Experimental Therapeutics

Cornel Catoi, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Cluj-Napoca, Romania

Department of Pathologic Anatomy, Necropsy and Veterinary Forensic Medicine

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Published

2016-02-02

How to Cite

1.
Visan S, Balacescu O, Berindan-Neagoe I, Catoi C. In vitro comparative models for canine and human breast cancers. Med Pharm Rep [Internet]. 2016 Feb. 2 [cited 2025 Oct. 5];89(1):38-49. Available from: https://medpharmareports.com/index.php/mpr/article/view/519

Issue

Section

Reviews