An Overview Of Pharmacology And Clinical Aspects Concerning The Therapy Of Cochleo-vestibular Syndromes By Intratympanic Drug Delivery

Authors

  • Felician Chirteş
  • Silviu Albu

Keywords:

intratympanic drug delivery, hemato-labirinthine barrier, intralabirinthine pharmacokinetics, intratympanic corticosteroids, intratympanic gentamicine

Abstract

Intratympanic drug delivery refers to drug administration in the middle ear, the main advantage being direct diffusion of substances in the inner ear through the round window membrane with subsequent high intralabiryntine drug concentration and very low systemic side effects. The article is a review of literature concerning the inner ear barrier systems, the physiology of inner ear fluids, intralabirinthine pharmacokinetics and the commonest drugs applied in the middle ear for the treatment of cochleo-vestibular syndromes.

Vol 86, No 3 (2013)

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Published

2014-02-14

How to Cite

1.
Chirteş F, Albu S. An Overview Of Pharmacology And Clinical Aspects Concerning The Therapy Of Cochleo-vestibular Syndromes By Intratympanic Drug Delivery. Med Pharm Rep [Internet]. 2014 Feb. 14 [cited 2025 Oct. 6];86(3):185-91. Available from: https://medpharmareports.com/index.php/mpr/article/view/53

Issue

Vol. 86 No. 3 (2013)

Section

Reviews

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