Prevalence and predictors of non-alcoholic fatty liver disease as defined by the fatty liver index in a type 2 diabetes population

Authors

  • Cristina Alina Silaghi
  • Horatiu Silaghi
  • Horatiu Alexandru Colosi
  • Anca Elena Craciun
  • Anca Farcas
  • Daniel Tudor Cosma
  • Nicolae Hancu
  • Raluca Pais
  • Carmen Emanuela Georgescu

DOI:

https://doi.org/10.15386/cjmed-544

Keywords:

nonalcoholic fatty liver disease, fatty liver index, risk factors, type 2 diabetes.

Abstract

Background and aims. We aimed to study prevalence  and the predictive factors of non-alcoholic fatty liver disease (NAFLD) defined by the fatty liver index (FLI) in type 2 diabetic patients (T2DM).

Methods. Three hundred and eighty-one T2DM outpatients who regularly attended a Consulting Clinic in Cluj were retrospectivelly included. FLI, a surrogate steatosis biomarker based on body mass index (BMI), waist circumference (WC), triglycerides (TGL) and gammaglutamyl-transferase (GGT) was used to assess NAFLD in all patients. Anthropometric and biochemical parameters were measured. Hepatic steatosis (HS) was evaluated by ultrasonography.

Results. NAFLD-FLI (defined as FLI >60) was correlated with HS evaluated by ultrasound (r=0.28; p<0.001). NAFLD-FLI was detected in 79% of T2DM. The prevalence of obesity in NAFLD-FLI patients was 80%. Of the patients with normal alanine aminotransferase (ALAT), 73.8 % had NAFLD. At univariate analysis, NAFLD-FLI was correlated with age (r= -0.14; p=0.007), sex (r=0.20; p<0.001), LDL cholesterol (r=0.12; p=0.032), HDL cholesterol (r = -0.13; p=0.015), ALAT (r=0.20; p<0.001) and ASAT (r=0.19; p<0.001). At multiple regression analysis, sex, ALAT and LDL-cholesterol were independent predictors of NAFLD-FLI. After logistic regression model, ALAT, LDL-cholesterol, HOMA-IR were good independent predictors of NAFLD-FLI.

Conclusions. NAFLD-FLI could be useful to identify NAFLD in T2DM patients. Subjects with T2DM had a high prevalence of NADLD-FLI even with normal ALAT levels . Our findings showed that sex, ALAT, LDL cholesterol and IR were significant and independent factors associated with the presence of NAFLD in T2DM subjects.

Author Biographies

Cristina Alina Silaghi, County Clinic Emergency Hospital University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca

Endocrinology

Horatiu Silaghi, 5th Surgery Department, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj Napoca

5th Surgery Department,

Horatiu Alexandru Colosi, Medical Informatics and Biostatistics Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca

Medical Informatics and Biostatistics Department

Anca Elena Craciun, Diabet, Nutrition and Metabolic Diseases Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca; Regina Maria Clinic, Cluj-Napoca;

Diabet, Nutrition and Metabolic Diseases Department

Anca Farcas, 1st Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca; Regina Maria Clinic, Cluj-Napoca

1st Internal Medicine Department

Daniel Tudor Cosma, County Clinic Emergency Hospital, Cluj-Napoca; Diabet, Nutrition and Metabolic Diseases Department, "Iuliu Hatieganu" University of Medicine and Pharmacy,

Diabet, Nutrition and Metabolic Diseases Department

Nicolae Hancu, Regina Maria Clinic, Cluj-Napoca

Diabet, Nutrition and Metabolic Diseases Department

Raluca Pais, Service Hépatogastroentérologie, Hôpital Pitié- Salpêtrière, Université Pierre et Marie Curie, INSERM UMRS 938, Paris

Service Hépatogastroentérologie, Hôpital Pitié- Salpêtrière,

Carmen Emanuela Georgescu, Endocrinology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca

Endocrinology Department

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Published

2016-02-02

How to Cite

1.
Silaghi CA, Silaghi H, Colosi HA, Craciun AE, Farcas A, Cosma DT, Hancu N, Pais R, Georgescu CE. Prevalence and predictors of non-alcoholic fatty liver disease as defined by the fatty liver index in a type 2 diabetes population. Med Pharm Rep [Internet]. 2016 Feb. 2 [cited 2025 Oct. 5];89(1):82-8. Available from: https://medpharmareports.com/index.php/mpr/article/view/544

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Section

Original Research