Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies

Authors

  • Olga Hilda Orasan Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca
  • George Ciulei Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca
  • Angela Cozma Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca
  • Madalina Sava Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca
  • Dan Lucian Dumitrascu Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca

DOI:

https://doi.org/10.15386/cjmed-554

Keywords:

hyaluronic acid, liver fibrosis, chronic liver diseases

Abstract

Chronic liver diseases represent a significant public health problem worldwide. The degree of liver fibrosis secondary to these diseases is important, because it is the main predictor of their evolution and prognosis.

Hyaluronic acid is studied as a non-invasive marker of liver fibrosis in chronic liver diseases, in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of fibrosis. We review the advantages and limitations of hyaluronc acid, a biomarker, used to manage patients with chronic viral hepatitis B or C infection, non-alcoholic fatty liver disease, HIV-HCV coinfection, alcoholic liver disease, primary biliary cirrhosis, biliary atresia, hereditary hemochromatosis and cystic fibrosis.

 

Author Biographies

Olga Hilda Orasan, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca

4th Medical Department

George Ciulei, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca

4th Medical Department

Angela Cozma, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca

4th Medical Department

Madalina Sava, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca

4th Medical Department

Dan Lucian Dumitrascu, Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca

2nd Medical Department

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Published

2016-02-02

How to Cite

1.
Orasan OH, Ciulei G, Cozma A, Sava M, Dumitrascu DL. Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies. Medicine and Pharmacy Reports [Internet]. 2016 Feb. 2 [cited 2025 Jun. 13];89(1):24-31. Available from: https://medpharmareports.com/index.php/mpr/article/view/554

Issue

Vol. 89 No. 1 (2016)

Section

Reviews

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