MicroRNAs as non-invasive screening biomarkers of colorectal cancer

Authors

  • Roberta Maria Manzat Saplacan
  • Petru Adrian Mircea
  • Loredana Balacescu
  • Ovidiu Balacescu

DOI:

https://doi.org/10.15386/cjmed-568

Keywords:

colorectal cancer, miRNAs, biomarkers, diagnostic

Abstract

Colorectal cancer is a major cause of cancer-associated deaths in the world. Early detection would be greatly enhanced if accurate and cost-effective diagnostic biomarkers for this disease were accessible. The development of such a blood test will evidently lower the screening costs in regards of colorectal cancer detection. Lately, it has been suggested that microRNA diagnostic biomarkers are feasible new screening methods for colorectal cancer. This review summarizes the diagnostic potential of circulating microRNA biomarkers in relation with colorectal cancer, as well as current methods to detect them.

 

Author Biographies

Roberta Maria Manzat Saplacan, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Ist Medical Clinic, 3-5 Clinicilor Street, Zip code 400006, Cluj-Napoca, Romania

Department of Internal Medicine

Petru Adrian Mircea, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Ist Medical Clinic, 3-5 Clinicilor Street, Zip code 400006, Cluj-Napoca, Romania

Department of Internal Medicine

Loredana Balacescu, The Oncology Institute “Prof. Dr. Ion Chiricuta” Cluj-Napoca, 34-36 Republicii Street, Zip code 400015, Cluj-Napoca, Romania

Department of Functional Genomics, Proteomics and Experimental Pathology

Ovidiu Balacescu, The Oncology Institute “Prof. Dr. Ion Chiricuta” Cluj-Napoca, 34-36 Republicii Street, Zip code 400015, Cluj-Napoca, Romania

Department of Functional Genomics, Proteomics and Experimental Pathology

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Published

2015-09-21

How to Cite

1.
Manzat Saplacan RM, Mircea PA, Balacescu L, Balacescu O. MicroRNAs as non-invasive screening biomarkers of colorectal cancer. Med Pharm Rep [Internet]. 2015 Sep. 21 [cited 2025 Oct. 3];88(4):453-6. Available from: https://medpharmareports.com/index.php/mpr/article/view/568

Issue

Vol. 88 No. 4 (2015)

Section

Reviews

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