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Copyright
© Clujul Medical, 2019
Affiliations
Cristina Ligia Cebotaru
Institute of Oncology`Prof Dr Ion Chiricuta` Cluj Napoca, Romania
Elena Diana Olteanu
Ion Chiricuta Institute of Oncology, Cluj-Napoca
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca
Nicoleta Zenovia Antone
Ion Chiricuta Institute of Oncology, Cluj-Napoca
Rares Buiga
Ion Chiricuta Institute of Oncology, Cluj-Napoca
Viorica Nagy
Ion Chiricuta Institute of Oncology, Cluj-Napoca
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca
How to Cite
Circulating tumor cells in germ cell tumors: are those biomarkers of real prognostic value? A review
Abstract
Analysis of circulating tumor cells from patients with different types of cancer is nowadays a fascinating new tool of research and their number is proven to be useful as a prognostic factor in metastatic breast, colon, and prostate patients. Studies are going beyond enumeration, exploring the circulating tumor cells to better understand the mechanisms of tumorigenesis, invasion, and metastasis and their value for characterization, prognosis and tailoring of treatment. Few studies investigated the prognostic significance of circulating tumor cells in germ cell tumors. In this review, we examine the possible significance of the detection of circulating tumor cells in this setting.