Circulating tumor cells in germ cell tumors: are those biomarkers of real prognostic value? A review

Authors

  • Cristina Ligia Cebotaru
  • Elena Diana Olteanu
  • Nicoleta Zenovia Antone
  • Rares Buiga
  • Viorica Nagy

DOI:

https://doi.org/10.15386/cjmed-570

Keywords:

germ cell tumors, circulating tumor cells, biomarkers

Abstract

Analysis of circulating tumor cells from patients with different types of cancer is nowadays a fascinating new tool of research and their number is proven to be useful as a prognostic factor in metastatic breast, colon, and prostate patients. Studies are going beyond enumeration, exploring the circulating tumor cells to better understand the mechanisms of tumorigenesis, invasion, and metastasis and their value for characterization, prognosis and tailoring of treatment. Few studies investigated the prognostic significance of circulating tumor cells in germ cell tumors. In this review, we examine the possible significance of the detection of circulating tumor cells in this setting.

Author Biographies

Cristina Ligia Cebotaru, Institute of Oncology`Prof Dr Ion Chiricuta` Cluj Napoca, Romania

Radiotherapy I Medical Oncology

Elena Diana Olteanu, Ion Chiricuta Institute of Oncology, Cluj-Napoca Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

Ion Chiricuta Institute of Oncology, Cluj-Napoca

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

Nicoleta Zenovia Antone, Ion Chiricuta Institute of Oncology, Cluj-Napoca

Ion Chiricuta Institute of Oncology, Cluj-Napoca

Rares Buiga, Ion Chiricuta Institute of Oncology, Cluj-Napoca

Ion Chiricuta Institute of Oncology, Cluj-Napoca

Viorica Nagy, Ion Chiricuta Institute of Oncology, Cluj-Napoca Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

Ion Chiricuta Institute of Oncology, Cluj-Napoca
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

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Published

2016-04-21

How to Cite

1.
Cebotaru CL, Olteanu ED, Antone NZ, Buiga R, Nagy V. Circulating tumor cells in germ cell tumors: are those biomarkers of real prognostic value? A review. Med Pharm Rep [Internet]. 2016 Apr. 21 [cited 2025 Oct. 5];89(2):203-11. Available from: https://medpharmareports.com/index.php/mpr/article/view/570

Issue

Vol. 89 No. 2 (2016)

Section

Reviews

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