Hypersensitivity and Nanoparticles: Update and Research Trends

Authors

  • Teodora Mocan
  • Cristian T. Matea
  • Cornel Iancu
  • Lucia Agoston-Coldea
  • Lucian Mocan
  • Remus Orasan

DOI:

https://doi.org/10.15386/cjmed-574

Keywords:

Nanoparticles, hypersensitivity, allergy

Abstract

Nanotechnology holds a great promise for a wide range of medical-intent applications (diagnostic, treatment and prophylaxis of various diseases). Their advantages are due to their size, versatility and potential for multiple simultaneous applications. However, concerns have been formulated by scientific world due to insufficient data on toxicity of nanomaterials. One area of interest is represented by the interactions between nanoparticles and the components of the immune system. We review herein reported data on hypersensitivity reactions. The role exerted by nanoparticles in both immunostimulation and immunosuppression in allergen-driven mechanisms was studied, as well as future trends in worldwide research.

Author Biographies

Teodora Mocan, 1Department of Physiology, University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania, 2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;

1Department of Physiology

2Nanomedicine Department

Cristian T. Matea, Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;

2Nanomedicine Department,

Cornel Iancu, 2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696 4Department of Surgery (3-rd Surgery Clinic), University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania

2Nanomedicine Department

4Department of Surgery (3-rd Surgery Clinic)

Lucia Agoston-Coldea, 2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696; 3Department of Internal Medicine (2-nd Medical Clinic), University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania,

2Nanomedicine Department

3Department of Internal Medicine (2-nd Medical Clinic)

Lucian Mocan, 2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696; 4Department of Surgery (3-rd Surgery Clinic), University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania

2Nanomedicine Department

4Department of Surgery (3-rd Surgery Clinic)

Remus Orasan, 1Department of Physiology, University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania, 2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;

1Department of Physiology

2Nanomedicine Department

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Published

2016-04-21

How to Cite

1.
Mocan T, Matea CT, Iancu C, Agoston-Coldea L, Mocan L, Orasan R. Hypersensitivity and Nanoparticles: Update and Research Trends. Med Pharm Rep [Internet]. 2016 Apr. 21 [cited 2025 Oct. 5];89(2):216-9. Available from: https://medpharmareports.com/index.php/mpr/article/view/574

Issue

Vol. 89 No. 2 (2016)

Section

Reviews

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