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Copyright
© Clujul Medical, 2019
Affiliations
Teodora Mocan
1Department of Physiology, University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania,
2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;
Cristian T. Matea
Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;
Cornel Iancu
2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696
4Department of Surgery (3-rd Surgery Clinic), University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania
Lucia Agoston-Coldea
2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;
3Department of Internal Medicine (2-nd Medical Clinic), University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania,
Lucian Mocan
2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;
4Department of Surgery (3-rd Surgery Clinic), University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania
Remus Orasan
1Department of Physiology, University of Medicine and Pharmacy, “Iuliu Hatieganu,” Croitorilor 19-21, Cluj-Napoca, Romania,
2Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology Octavian Fodor Cluj tel/fax: +40264-439696;
How to Cite
Hypersensitivity and Nanoparticles: Update and Research Trends
Abstract
Nanotechnology holds a great promise for a wide range of medical-intent applications (diagnostic, treatment and prophylaxis of various diseases). Their advantages are due to their size, versatility and potential for multiple simultaneous applications. However, concerns have been formulated by scientific world due to insufficient data on toxicity of nanomaterials. One area of interest is represented by the interactions between nanoparticles and the components of the immune system. We review herein reported data on hypersensitivity reactions. The role exerted by nanoparticles in both immunostimulation and immunosuppression in allergen-driven mechanisms was studied, as well as future trends in worldwide research.