Severe hemolytic disease of the premature newborn due to RH1 incompatibility: a case report

Authors

  • Jean Uwingabiye
  • Hafid Zahid
  • Fayçal Labrini
  • Abdelhak El Khazraji
  • Anass Yahyaoui
  • Rachid Hadef
  • Nezha Messaoudi

DOI:

https://doi.org/10.15386/cjmed-578

Keywords:

Hemolytic disease of the newborn, allo-immunization, prevention, RH1

Abstract

We report a case of dramatic outcome of severe haemolytic disease in a newborn due to RH1 incompatibility. A newborn with A RH1 blood group was admitted in the Mohammed V Military Teaching Hospital for the problem of hydrops fetalis associated with RH1 incompatibility. The blood group of his mother, aged 31, was AB RH1-negative and that of his 37 year old father was A RH1.The mother had a history of 4 term deliveries, 3 abortions, and 1 living child. There was no prevention by anti-D immunoglobulin postpartum. The mother‘s irregular agglutinin test was positive and the pregnancy was poorly monitored. The laboratory tests of the newborn showed a high total serum bilirubin level (30 mg/L) and macrocytic regenerative anemia (Hemoglobin=4 g/dL, mean corpuscular volume = 183 fL, reticulocytes count =176600/m3). The blood smear showed 1256 erythroblasts per 100 leukocytes, Howell–Jolly bodies and many macrocytes. The direct antiglobulin test was positive. He was transfused with red blood cell concentrates and treated with conventional phototherapy. The evolution was unfavourable; he died three days after the death of his mother. The monitoring of these high-risk pregnancies requires specialized centers and a close collaboration between the gynaecologist and the blood transfusion specialist to strengthen the prevention, as well as clinico-biological monitoring in patients with a history of RH1 fetomaternal alloimunization.

Author Biographies

Jean Uwingabiye, Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of  Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Hafid Zahid, Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of  Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Fayçal Labrini, Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of  Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Abdelhak El Khazraji, Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of  Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Anass Yahyaoui, Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of  Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Rachid Hadef, Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of  Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Nezha Messaoudi, Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

Laboratory of Hematology and Immuno-hematology; Mohammed V Military Teaching Hospital, Faculty of  Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

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Published

2016-10-28

How to Cite

1.
Uwingabiye J, Zahid H, Labrini F, El Khazraji A, Yahyaoui A, Hadef R, Messaoudi N. Severe hemolytic disease of the premature newborn due to RH1 incompatibility: a case report. Med Pharm Rep [Internet]. 2016 Oct. 28 [cited 2025 Oct. 6];89(4):565-8. Available from: https://medpharmareports.com/index.php/mpr/article/view/578

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Section

Case Report