Matrix Gla protein in tumoral pathology

Authors

  • Simona Roxana Gheorghe
  • Alexandra Mărioara Crăciun

DOI:

https://doi.org/10.15386/cjmed-579

Keywords:

matrix gla protein, ectopic calcification, angiogenesis, tumorigenesis

Abstract

Matrix Gla protein is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. The presence of matrix Gla protein was reported in arterial and venous walls, lungs, kidney, uterus, heart, tooth cementum and eyes. Several studies identified matrix Gla protein in tumoral pathology.

Until recently, it was thought to only have an inhibitory role of physiological and ectopic calcification. New studies demonstrated that it also has a role in physiological and pathological angiogenesis, as well as in tumorigenesis.

The aim of this review is to report the latest findings related to the expression and clinical implications of matrix Gla protein in different types of cancer with an emphasis on cerebral tumors.

Author Biographies

Simona Roxana Gheorghe, University of Medicine and Pharmacy "Iuliu Hațieganu" Cluj-Napoca

Medical Biochemistry

Alexandra Mărioara Crăciun, University of Medicine and Pharmacy "Iuliu Hațieganu" Cluj-Napoca

Medical Biochemistry

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Published

2016-07-31

How to Cite

1.
Gheorghe SR, Crăciun AM. Matrix Gla protein in tumoral pathology. Med Pharm Rep [Internet]. 2016 Jul. 31 [cited 2025 Oct. 5];89(3):319-21. Available from: https://medpharmareports.com/index.php/mpr/article/view/579

Issue

Vol. 89 No. 3 (2016)

Section

Reviews

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