McCune Albright syndrome - association of fibrous dysplasia, café-au-lait skin spots and hyperthyroidism – case report

Authors

  • Iulian Raus
  • Roxana Elena Coroiu

DOI:

https://doi.org/10.15386/cjmed-624

Keywords:

bone fibrous dysplasia, café-au-lait lesions, MRI, hyperthyroidism

Abstract

McCune–Albright syndrome is a rare sporadic disease characterized by bone fibrous dysplasia, café-au-lait skin spots and a variable association of hyperfunctional endocrine disorders. Fibrous dysplasia (FD), which can involve the craniofacial, axial, and appendicular skeleton, may range from an isolated, asymptomatic monostotic lesion to a severe disabling polyostotic disease involving the entire skeleton. A twenty-five-year old male patient presented to our clinic with recently developed heart palpitations. He had also been feeling pain in the right femur since he was younger, without any trauma history, leading to difficulties of ambulation and limping occasionally. His physical examination revealed café-au-lait spots with irregular borders and right testicular agenesis. Laboratory findings identified hyperthyroidism with hyperparathyroidism. Radiographs of the pelvis revealed multiple lytic lesions of the right femur and magnetic resonance imaging (MRI) characterized these lesions as specific to fibrous dysplasia of the bone, without any insufficiency fracture at this level.

The association of café-au-lait skin spots with bone fibrous dysplasia, and hyperthyroidism in this patient suggested the diagnosis of McCune – Albright syndrome.

Author Biographies

Iulian Raus, Dr. Constantin Papilian Military and Emergency Hospital of Cluj-Napoca

Department of Radiology

Roxana Elena Coroiu, Iuliu Haţieganu University of Medicine and Pharmacy of Cluj-Napoca

Department of Radiology

Downloads

Published

2016-10-28

How to Cite

1.
Raus I, Coroiu RE. McCune Albright syndrome - association of fibrous dysplasia, café-au-lait skin spots and hyperthyroidism – case report. Med Pharm Rep [Internet]. 2016 Oct. 28 [cited 2025 Oct. 6];89(4):559-64. Available from: https://medpharmareports.com/index.php/mpr/article/view/624

Issue

Section

Case Report