Ferritin level changes and erythroid improvement in a group of adult politransfused patients treated with Deferasirox

Authors

  • Andrada Viorica Parvu
  • Anca Bojan
  • Laura Urian
  • Tunde Torok
  • Iulia Andrea Zsoldos
  • Mihaela Iancu

DOI:

https://doi.org/10.15386/cjmed-942

Keywords:

iron overload, iron chelating therapy, anemia

Abstract

Background and aims. Chelating agents therapy is recommended for polytransfused patients that have evidence of iron overload (an elevated serum ferritin or received over 20 units of red blood cell transfusions). Deferasirox showedefficacy and safety in maintaining or reducing body iron.Iron chelation therapy was associated with hematopoiesis improvement in transfusion-dependent patients.

Our objectives were to analyze differences in ferritin level in adult polytransfused patients treated with Deferasirox, to estimate the erythroid improvement and variation of the number of red blood cell transfusion after introducing Deferasirox, to evaluate the side effects of the treatment.

Methods. Retrospective study including all the adult polytransfused patients treated with Deferasirox in Hematology Departments of   three county hospitals in the North-West of Romania.         

Results. We included 40 polytransfused patients treated with Deferasirox in standard doses. There was a significant reduction in serum ferritine from baseline for all the patients (Friedman test, χ2(2)=26.82, p<0.001). Safety profile of Deferasirox was good (three digestive side effects). RBCT were administered before (mean 2.43±1.09 units/month) and after starting Deferasirox (mean 1.40±0.97 units/month), the difference is statistically significant (Student Test, t(39)=6.98, p<0.001).

Conclusions. Deferasirox proves to be an effective iron chelator, the serum level of ferritine decreased for all the patients during the treatment and 22.5 % of the patients developed an erythroid improvement. Safety and compliance were good.

Author Biographies

Andrada Viorica Parvu, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca

Hematology

Anca Bojan, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca

Hematology

Laura Urian, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca

Hematology

Tunde Torok, "Iuliu Hatieganu" University of medicine and Pharmacy, Cluj-Napoca

Hematology

Iulia Andrea Zsoldos, "Iuliu Hatieganu" University of Mrdicine and Pharmacy, Cluj-Napoca

Hematology

Mihaela Iancu, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca

Medical Informatics and Biostatistics

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Published

2018-07-24

How to Cite

1.
Parvu AV, Bojan A, Urian L, Torok T, Zsoldos IA, Iancu M. Ferritin level changes and erythroid improvement in a group of adult politransfused patients treated with Deferasirox. Med Pharm Rep [Internet]. 2018 Jul. 24 [cited 2025 Oct. 5];91(3):288-92. Available from: https://medpharmareports.com/index.php/mpr/article/view/942

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Section

Original Research