Fecal transplantation: digestive and extradigestive clinical applications

Authors

  • Mihaela Filip
  • Valentina Tzaneva
  • Dan L. Dumitrascu

DOI:

https://doi.org/10.15386/cjmed-946

Keywords:

fecal transplantation, IBS, IBD, intestinal diseases

Abstract

Background and aim. Fecal transplantation or fecal material transplantation (FMT) became a hot topic in gastroenterology in recent years. Therefore it is important to disseminate the up-to-date information on FMT. The aim of the paper is to review the knowledge on FMT and its clinical applications.

Methods. An extensive review of the literature was carried out. Titles from Pubmed were searched and analyzed. A narrative review has been written with emphasis on indications of FMT in different conditions.

Results. The guidelines recommend FMT in relapsing infection with Clostridium difficile. Several attempts to use FMT in other conditions have been analyzed. Attempts were recorded in other bowel disorders like IBD, IBS, chronic constipation and even colorectal cancer. The attempt to change the microbiota by FMT in diabetes and obesity represent challenges for the future.

Conclusions. Fecal transplantation represents an important therapeutic method, intensively investigated these years. Beside the indication for persistent and recurrent Clostridium difficile infection, several attempts were undertaken in other intestinal diseases and in metabolic conditions. The efficiency of these applications has to be demonstrated.

Author Biographies

Mihaela Filip, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca

2nd Dept. Internal Medicine

Valentina Tzaneva, Trakia University Stara Zagora,

Trakia University Stara Zagora,

Dan L. Dumitrascu, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca

2nd Dept. Internal Medicine

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Published

2018-07-24

How to Cite

1.
Filip M, Tzaneva V, Dumitrascu DL. Fecal transplantation: digestive and extradigestive clinical applications. Med Pharm Rep [Internet]. 2018 Jul. 24 [cited 2025 Oct. 5];91(3):259-65. Available from: https://medpharmareports.com/index.php/mpr/article/view/946

Issue

Section

Reviews