NON-ALCOHOLIC FATTY LIVER DISEASE: AN UPDATE ON DIAGNOSIS

Authors

  • Dan L. Dumitrascu
  • Manuela G. Neuman

DOI:

https://doi.org/10.15386/cjmed-993

Keywords:

fibrosis, imaging, non-alcoholic fatty liver, laboratory markers, nonalcoholic steatohepatitis

Abstract

Background and aim. The non-alcoholic fatty liver disease (NAFLD) and its sub-entity, the non-alcoholic steatohepatitis (NASH) represent a field of a tremendous progress in recent years. Clinicians need to remain updated with new data on pathogenesis and therapy. The present mini review aims to present some new scientific reports on the diagnosis of NAFLD and NASH for clinical practitioners.

Methods. A systematic literature search of the main international databases was performed. We looked for seminal and innovative papers published in main international languages. A narrative review of the topic was consequently written.

Results. This review describes new data on the diagnosis of NAFLD including NASH. Liver punction biopsy remains the gold standard. However many patients and clinicians prefer to use noninvasive methods. We present the serological tests and the imaging methods used to diagnose inflammation and fibrosis occurring in NAFLD and NASH.

Conclusions. NAFLD-NASH are multifaceted entities that have to be diagnosed and treated by skilled and informed practitioners.

Author Biographies

Dan L. Dumitrascu, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca

Manuela G. Neuman, 1In Vitro Drug Safety and Biotechnology; Toronto, Ontario 2Faculty of Medicine, University of Toronto, Toronto, Ontario

Pharmacology and Toxicology

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Published

2018-04-26

How to Cite

1.
Dumitrascu DL, Neuman MG. NON-ALCOHOLIC FATTY LIVER DISEASE: AN UPDATE ON DIAGNOSIS. Med Pharm Rep [Internet]. 2018 Apr. 26 [cited 2025 Oct. 5];91(2):147-50. Available from: https://medpharmareports.com/index.php/mpr/article/view/993

Issue

Vol. 91 No. 2 (2018)

Section

Reviews

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