Association between hypertension and microvascular and macrovascular complications among patients with type 2 diabetes: a cross-sectional study

Authors

  • Asmae Salhi
  • Hanae Bakmizi
  • Rania El Amel
  • Latifa Boutaybi
  • Nisrine Bouichrat
  • Siham Rouf
  • Hanane Latrech

DOI:

https://doi.org/10.15386/mpr-2978

Keywords:

diabetes mellitus, type 2, hypertension, diabetes complications, diabetic angiopathies, cross-sectional studies

Abstract

Background

Hypertension frequently coexists with type 2 diabetes (T2D) and may contribute to the development of diabetic complications.

Objective

This study aimed to assess the association between hypertension and microvascular and macrovascular complications in patients with type 2 diabetes (T2D).

Methods

We conducted a retrospective cross-sectional study based on a review of medical records, including 500 patients with T2D followed in the Department of Endocrinology, Diabetology, and Nutrition. Patients were grouped according to the presence of hypertension, with 204 patients in the hypertension group and 296 patients in the non-hypertension group. Clinical, biological, and complication-related data were collected and analyzed using appropriate statistical methods.

Results

The mean age was 58.3 ± 12.8 years, and hypertension was present in 40.8% of cases. Poor glycemic control (glycated hemoglobin [HbA1c] >10%) was observed in 52.2%. Patients with hypertension had higher frequencies of several microvascular and macrovascular complications compared with patients without hypertension. Nephropathy was more frequent among patients with hypertension than among those without hypertension (32.8% vs. 14.2%; OR = 2.96, 95% CI: 1.91–4.58; p < 0.001). Higher grades of hypertension were significantly associated with peripheral arterial disease and cerebrovascular accident. Longer diabetes duration was associated with retinopathy, neuropathy, and cerebrovascular accident, whereas longer hypertension duration was significantly associated with peripheral arterial disease.

Conclusions

Hypertension is significantly associated with a higher prevalence of both microvascular and macrovascular complications in patients with T2D. These findings support the importance of early identification and integrated management of hypertension, glycemic control, and other cardiovascular risk factors to reduce the burden of diabetic complications.

 

Ahead

Downloads

Published

2026-10-29

How to Cite

1.
Salhi A, Bakmizi H, El Amel R, Boutaybi L, Bouichrat N, Rouf S, Latrech H. Association between hypertension and microvascular and macrovascular complications among patients with type 2 diabetes: a cross-sectional study. Med Pharm Rep [Internet]. 2026 Oct. 29 [cited 2026 Oct. 30];. Available from: https://medpharmareports.com/index.php/mpr/article/view/2978

Issue

Ahead of print

Section

Original Research

License

Copyright (c) 2026 Asmae Salhi, Hanae Bakmizi, Rania El Amel, Latifa Boutaybi, Nisrine Bouichrat, Siham Rouf, Hanane Latrech

The authors are required to transfer the copyright of the published paper to the journal. This is done by agreeing to sign the Copyright Assignment Form. Whenever the case, authors are also required to send permissions to reproduce material (such as illustrations) from the copyright holder.

 Creative Commons License
The papers published in the journal are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.