Next generation sequencing applications for breast cancer research

Authors

  • Roxana Cojocneanu Petric
  • Laura-Ancuta Pop
  • Ancuta Jurj
  • Lajos Raduly
  • Dan Dumitrascu
  • Nicolae Dragos
  • Ioana Berindan Neagoe

DOI:

https://doi.org/10.15386/cjmed-486

Keywords:

breast cancer, benchtop sequencers, genome, next generation sequencing (NGS), personalized therapy

Abstract

For some time, cancer has not been thought of as a disease, but as a multifaceted, heterogeneous complex of genotypic and phenotypic manifestations leading to tumorigenesis. Due to recent technological progress, the outcome of cancer patients can be greatly improved by introducing in clinical practice the advantages brought about by the development of next generation sequencing techniques. Biomedical suppliers have come up with various applications which medical researchers can use to characterize a patient’s disease from molecular and genetic point of view in order to provide caregivers with rapid and relevant information to guide them in choosing the most appropriate course of treatment, with maximum efficiency and minimal side effects. Breast cancer, whose incidence has risen dramatically, is a good candidate for these novel diagnosis and therapeutic approaches, particularly when referring to specific sequencing panels which are designed to detect germline or somatic mutations in genes that are involved in breast cancer tumorigenesis and progression.  Benchtop next generation sequencing machines are becoming a more common presence in the clinical setting, empowering physicians to better treat their patients, by offering early diagnosis alternatives, targeted remedies, and bringing medicine a step closer to achieving its ultimate goal, personalized therapy.

Author Biographies

Roxana Cojocneanu Petric, 1. Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania 2. Faculty of Biology and Geology, Babes Bolyai Univesity Cluj-Napoca, Romania 3. The Oncology Institute "Prof. Dr. I. Chiricuta" Cluj-Napoca, Romania

Research Center for Functional Genomics, Biomedicine and Translational Medicine

Laura-Ancuta Pop, 1-The Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 2- Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania

Research Center for Functional Genomics, Biomedicine and Translational Medicine

Ancuta Jurj, Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania

Research Center for Functional Genomics, Biomedicine and Translational Medicine

Lajos Raduly, 1. Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania 2. University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania

Research Center for Functional Genomics, Biomedicine and Translational Medicine

Dan Dumitrascu, 2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

2nd Department of Internal Medicine

Nicolae Dragos, NIRDBS - Institute of Biological Research, Cluj-Napoca, Romania

Taxonomy and Ecology

Ioana Berindan Neagoe, 1. Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 2. Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA 3. Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania 4. Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

Research Center for Functional Genomics, Biomedicine and Translational Medicine

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Published

2015-07-22

How to Cite

1.
Cojocneanu Petric R, Pop L-A, Jurj A, Raduly L, Dumitrascu D, Dragos N, Berindan Neagoe I. Next generation sequencing applications for breast cancer research. Med Pharm Rep [Internet]. 2015 Jul. 22 [cited 2025 Oct. 5];88(3):278-87. Available from: https://medpharmareports.com/index.php/mpr/article/view/486

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Section

Reviews