XRCC3 Thr241Met polymorphism is not associated with lung cancer risk in a Romanian population

Authors

  • Andreea Catana
  • Monica Pop
  • Dragos Horea Marginean
  • Ioana Cristina Blaga
  • Mihai Dumitru Porojan
  • Radu Anghel Popp
  • Ioan Victor Pop

DOI:

https://doi.org/10.15386/cjmed-523

Keywords:

lunga cancer, XRCC3 gene, Trh241Met polymorphism

Abstract

Background and aims. Deoxyribonucleic Acid (DNA) repair mechanisms play a critical role in protecting the cellular genome against carcinogens. X-ray cross-complementing gene 3 (XRCC3) is involved in DNA repair and therefore certain genetic polymorphisms that occur in DNA repair genes may affect the ability to repair DNA defects and may represent a risk factor in carcinogenesis. The purpose of our study was to investigate the association between XRCC3 gene substitution of Threonine with Methionine in codon 241 of XRCC3 gene (Thr241Met) polymorphism and the risk of lung cancer, in a Romanian population.

Methods. We recruited 93 healthy controls and 85 patients with lung cancer, all smokers. Thr241Met, XRCC3 gene genotyping was determined by multiplex Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR–RFLP).

Results. Statistical analysis (OR, recessive model), did not revealed an increased risk for lung cancer, for the variant 241Met allele and Thr241Met genotypes (p=0.138, OR=0.634, CI=0.348-1.157; p=0.023, OR=0.257, CI=0.085-6.824). Also, there were no positive statistical associations between Thr241Met polymorphism of XRCC3 gene, gender, tobacco and various histopathological tumor type of lung cancer.

Conclusion. In conclusion, the results of the study suggest that the XRCC3 gene Thr241Met polymorphism is not associated with an increased risk for the development of lung cancer in this Romanian group.

 


 

 

Author Biographies

Andreea Catana, MD, PhD, Lecturer Department of Molecular Sciences UMF Iuliu hatieganu, Cluj

Department of molecular Sciene UMF Iuliu Hatieganu. cluj

Monica Pop, Professor, MD, PhD

Pneumology Department
UMF Iuliu Hatieganu, Cluj

Dragos Horea Marginean, MD

Molecular Sciences

UMF IuliuHatieganu, Cluj

Ioana Cristina Blaga, MD

Department of Molecular Sciences

UMF Iuliu Hatieganu, Cluj

Mihai Dumitru Porojan, MD, PhD

Internal Medicine

UMF Iuliu Hatieganu, Cluj

Radu Anghel Popp, Lecturer, MD, PhD

Molecular Sciences

UMF Iiuliu Hatieganu, Cluj

Ioan Victor Pop, Professor, MD, PhD

Molecular Sciences

UMF Iuliu Hatieganu, Cluj

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Published

2016-02-02

How to Cite

1.
Catana A, Pop M, Marginean DH, Blaga IC, Porojan MD, Popp RA, Pop IV. XRCC3 Thr241Met polymorphism is not associated with lung cancer risk in a Romanian population. Med Pharm Rep [Internet]. 2016 Feb. 2 [cited 2025 Oct. 6];89(1):89-93. Available from: https://medpharmareports.com/index.php/mpr/article/view/523

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Section

Original Research