BETTER PROGNOSIS IN OVERWEIGHT/OBESE CORONARY HEART DISEASE PATIENTS WITH HIGH PLASMA LEVELS OF LEPTIN

Authors

  • Luminita Animarie Vida Simiti
  • Irina Todor
  • Mirela Anca Stoia
  • Cerasela Mihaela Goidescu
  • Florin Petru Anton
  • Anca Daniela Farcas

DOI:

https://doi.org/10.15386/cjmed-524

Keywords:

leptin, coronary heart disease, owerweight, obesity, prognosis

Abstract

Background and aim. The involvement of leptin in atherosclerosis is very complex, including inflammation, the oxidative stress and thrombosis. Leptin has atherogenic and also antiatherogenic actions. In obesity elevated leptin levels are not sufficient to prevent disturbances of energy balance, suggesting that obese people are leptin resistant. The aim of the study was to investigate the relationship between baseline plasma levels of leptin and the incidence of new ischemic events in patients with CHD.

Methods. Plasma levels of leptin in fifty nine consecutive patients (29 men and 30 women) with CHD hospitalized in the County Emergency Clinical Hospital of Cluj-Napoca were measured using commercially available ELISA at admission. Patients with active infectious disease, neoplasia, acute coronary syndrome, stroke, hepatic or renal failure and severe heart failure were excluded The relationship between leptin levels and incident cardiovascular events (angina, nonfatal myocardial infarction or heart failure) over two years follow-up was studied using  MEDCALC version 9.6.

Results. 73.6% patients with CHD were overweight or suffered of obesity. There were no significant differences between women and men regarding the plasma levels of leptin, the body mass index (BMI), the number of rehospitalizations, rehospitalizations/patient, diabetes mellitus, hypertension or dyslipidemia. Only in women plasma levels of leptin are correlated with BMI. As compared with men with overweight and obesity (BMI ≥25kg/m2), plasma levels of leptin were significantly higher in women with overweight and obesity (3905.97±463.91 pg/ml vs 1835.17±533.9 pg/ml) (p<0.002). Patient gender could not be demonstrated to influence prognosis. During the two years we recorded one or more readmissions in 26 patients (44%). The analysis of time till readmission using Kaplan-Meier curves, showed that leptin level (cut-off 2000 pg/ml, HR 0.38, 95% CI 0.17-0.83; p=0.01) and BMI (cut-off 28 kg/m2, HR 0.3164, 95% CI 0.145-0.0689; p<0.01) were significantly associated with prognosis.

Conclusion. Patients with plasma levels of leptin >2000 pg/ml and BMI >28kg/m2 had a better prognosis, suggesting a protective role of leptin in overweight/mild obesity.

Author Biographies

Luminita Animarie Vida Simiti, "IULIU HATIEGANU UNIVERSITY" CLUJ NAPOCA

Internal Medicine Department,  Medical Clinic I - Internal Medicine, Cardiology and Gastroenterology

Irina Todor, Clinical Hospital County

Cardiology

Mirela Anca Stoia, "IULIU HATIEGANU UNIVERSITY" CLUJ NAPOCA

Internal Medicine Department,  Medical Clinic I - Internal Medicine, Cardiology and Gastroenterology

Cerasela Mihaela Goidescu, "IULIU HATIEGANU UNIVERSITY" CLUJ NAPOCA

Internal Medicine Department,  Medical Clinic I - Internal Medicine, Cardiology and Gastroenterology

Florin Petru Anton, "IULIU HATIEGANU UNIVERSITY" CLUJ NAPOCA

Internal Medicine Department,  Medical Clinic I - Internal Medicine, Cardiology and Gastroenterology

Anca Daniela Farcas, "IULIU HATIEGANU UNIVERSITY" CLUJ NAPOCA

Internal Medicine Department,  Medical Clinic I - Internal Medicine, Cardiology and Gastroenterology

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Published

2016-02-02

How to Cite

1.
Vida Simiti LA, Todor I, Stoia MA, Goidescu CM, Anton FP, Farcas AD. BETTER PROGNOSIS IN OVERWEIGHT/OBESE CORONARY HEART DISEASE PATIENTS WITH HIGH PLASMA LEVELS OF LEPTIN. Med Pharm Rep [Internet]. 2016 Feb. 2 [cited 2025 Oct. 5];89(1):65-71. Available from: https://medpharmareports.com/index.php/mpr/article/view/524

Issue

Vol. 89 No. 1 (2016)

Section

Original Research

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